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考拉西坦

简要描述:

产品名称:考拉西坦;Coluracetam
代号:BCI-540, MKC-231
化学名: N-(2,3-二甲基-5,6,7,8-四氢呋喃并[2,3-b]喹啉-4-基)-2-(2-氧代吡咯烷-1-基)乙酰胺
CAS:135463-81-9
外观:白色结晶性粉末。
纯度:99%
包装:5公斤/桶
用途:属于西坦类衍生物,主要应用于促智类产品。

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产品名称:考拉西坦;Coluracetam
代号:BCI-540, MKC-231
化学名:  N-(2,3-二甲基-5,6,7,8-四氢呋喃并[2,3-b]喹啉-4-基)-2-(2-氧代吡咯烷-1-基)乙酰胺
CAS:135463-81-9
外观:白色结晶性粉末。
纯度:99%
包装:5公斤/桶
用途:考拉西坦属于西坦类衍生物,主要应用于促智类产品。

Coluracetam

Product name:Coluracetam
Chemical name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide.
CODE:BCI-540, MKC-231
CAS:135463-81-9
Purity: 99%
Appearance: white crystalline powder
Package: 1kg/bag.

    Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD).BrainCells Inc is currently out-licensing the drug for this purpose.It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
    Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.

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